Which Sexual Dysfunction Treatments Can You Combine?

image of premature ejaculation and erectile dysfunction pills togetherMany readers have asked if it’s safe and effective to combine different premature ejaculation and/or erectile dysfunction treatments.

Sometimes it’s in the hope that a dual approach will be more effective. But it might also be that you suffer from two or more sexual problems at once.

If you’re thinking of doing the same, you’ll find some helpful information about the most common combinations people ask about here.

Please note that this article isn’t a substitute for medical advice. And as you’ll see below, the standard advice for most combinations is either to avoid them, or check with your personal physician or doctor first.

Why combine treatments?

Everyone has their own personal reason, of course. But the main reasons readers have expressed are to:

  • Improve premature ejaculation more than one treatment does
  • Overcome serious erection problems
  • Cope with the difficult issue of dual PE and ED
  • Increase erection size (and in some cases penis size)
  • Improve libido
  • Have sex more often and/or more times in one encounter

These are all very understandable reasons. But the question is, will two treatments work better than one, and is it safe?

A difficult questions to answer

Unfortunately, there isn’t always clear guidance about combining sexual dysfunction treatments.

There are several possible reasons why:

  • There isn’t enough clinical research into the safety and effectiveness
  • If scientists believe there could be serious adverse effects, they don’t risk testing with people
  • Your medical history and other medications are important to consider
  • Drug companies don’t tend to advise people to use their competitor’s products
  • With non-prescription treatments, there’s often limited guidance from the manufacturer

So even though I’ll look at some combinations below, please understand that this is often a grey area. And that other factors can play a key role in making a decision.

Should I consult my personal physician or doctor before combining treatments?

Yes, absolutely. Even if you can buy a treatment online, it’s still good to check if it’s safe to combine it with a different drug or remedy.

And in some cases, you might already have a medication because of a different condition, such as painkillers or anti-depressants.

In that situation, you should still check with your personal doctor before taking another sexual dysfunction treatment at the same time.

Common combinations men ask about

1. Tramadol and sildenafil (viagra)

Advice: avoid unless your doctor advises it

Why: The hope is that the viagra (or similar sildenafil products) will help with erectile dysfunction. And then the tramadol will prevent premature ejaculation.

There’s no available clinical research into this combination though. And medical sites like drugs.com don’t have any specific advice about it.

However, they are both strong drugs, with many potential side effects and warnings. So I don’t recommend experimenting with them without consulting your doctor.

2. Viagra and alcohol

Advice: don’t drink excessive amounts

Why: some men find that alcohol helps with premature ejaculation, and increases their sexual self-confidence. It also naturally goes with social situations, of course.

However, alcohol can cause erection problems, making viagra less effective. Here’s what the patient leaflet says:

Drinking alcohol can temporarily impair your ability to get an erection. To get the maximum benefit from your medicine, you are advised not to drink excessive amounts of alcohol before taking viagra.

image with the writing 'alcohol doesn't mix well with premature ejaculation and erectile dysfunction drugs'

3. Viagra and poppers (amyl nitrate)

Advice: avoid

Why: Some people use poppers to relax their muscles, making sex easier; others say it increases libido and lasting time.

But Pfizer (the manufacturer of viagra) specifically advises not to take this combination on the viagra patient leaflet. The reason is the risk of a dangerous blood pressure drop.

4. Priligy/dapoxetine and tramadol

Advice: avoid

Why: the manufacturer of priligy specifically warns against taking priligy and tramadol together because they can both affect blood pressure.

And if you take one, you need to wait before taking the other. Here’s what the priligy patient leaflet says:

Do not take Priligy at the same time as any of the medicines listed above (note – tramadol is on that list). If you have taken any of these medicines, you will need to wait 14 days after you stop taking it before you can start taking Priligy. Once you have stopped taking Priligy, you will need to wait 7 days before taking any of the medicines listed above

5. Priligy and erectile dysfunction drugs

Advice: discuss with your doctor first

Why: both priligy and some erectile dysfunction drugs can lower blood pressure. Unlike with tramadol though, the advice on the priligy patient leaflet is to check with your doctor first:

Tell your doctor or pharmacist if you are taking…certain medicines used to treat erectile dysfunction, such as sildenafil, tadalafil or vardenafil, as these medicines may lower your blood pressure, possibly upon standing

photo of a pack of priligy and viagra together

6. Priligy and alcohol

Advice: avoid

Why: the manufacturer advises against using alcohol with priligy. It can increase the effects of alcohol, such as dizziness and sleepiness, and increase the risk of accidents or fainting.

7. Priligy and desensitizing sprays / creams

Advice: discuss with your doctor first

Why: desensitizing sprays are one of the most popular over the counter treatments for premature ejaculation. And they tackle the problem in a completely different way to priligy.

There’s no information about the safety of combining both though. I contacted Promescent, the manufacturer of a lidocaine-based delay spray, and they advised consulting with a doctor first.

On a personal note, I tried this particular combination and didn’t have any additional problems beyond the side effects they have on their own. It also seemed more effective than when taking just one.

8. Desensitizing sprays and erectile dysfunction drugs

Advice: discuss with your doctor first

Why: there’s no official information available about using a delay spray with an ED drug. I also asked Promescent about this, and they offered this advice:

We don’t have any data on the combination of Promescent and other products or any side effects of combining them. We would always recommend they consult with a physician or doctor before using Promescent in combination with any prescription medication such as ED treatments.

On two occasions, I’ve tried viagra and a desensitizing spray. Once with promescent, and once with fortacin.

I found it helped with the issue of the spray causing erection problems, and didn’t cause additional noticeable side effects. But I still recommend checking with your own doctor first.

It’s also thought that viagra helps some men with premature ejaculation. So it might be better to try it alone to start with, rather than a combination therapy.

photo of different desensitizing sprays, numbing condoms and erectile dysfunction treatments together

9. Desensitizing sprays and numbing or normal condoms

Advice: fine with a normal latex condom. But not with a numbing condom.

Why: numbing condoms almost always contain benzocaine. Sprays/creams usually contain lidocaine, benzocaine or prilocaine.

It doesn’t help to apply two types of desensitizing at once though. The result is likely to be erection problems and an unpleasant burning sensation.

However, it’s fine to use both a delay spray and a normal condom, as long as it’s latex. You can find out more about using desensitizing sprays here.

10. Sildenafil and a vacuum erectile device (penis pump)

Advice: might help if the individual treatments aren’t effective enough.

Why: PDE5I drugs like sildenafil are the usual first-line treatment for ED. If it doesn’t help, a penis pump is often recommended next.

Researchers found that combining the two was a more effective treatment when one wasn’t good enough on its own.

All 41 men in the research study said they were more satisfied with the dual therapy. Though it was noted that younger men preferred this approach.

photo of a standard penis pump

11. Vacuum erectile device and desensitizing spray

Advice: there’s no available medical advice about this. My view is to be very careful if you try it.

Why: a common side effect of desensitizing products is difficulty in getting an erection. So a penis pump can help when that happens.

However, penis pumps can cause tissue damage and pain. So in my experience, you need to be very alert for any discomfort when you use it. If your penis has reduced sensitivity, it’s difficult to judge though.

So I advise not combining the two unless you check with your doctor first and take extra care.

12. Male enhancement pills and herbal remedy combinations

Advice: medical sources often advise avoiding unregulated over the counter pills. My view is that you should research them carefully and discuss with a doctor first.

Why: there are many pills sold online that promise to help with erectile dysfunction, premature ejaculation, low libido and sexual performance.

However, many are in the supplements category, and therefore untested and unregulated. This means they can be dangerous even on their own. So mixing them isn’t a good idea either.

There are undoubtedly herbal remedies that do work well, and have been used in traditional medicine around the world for hundreds of years.

Just be aware that they are often sold in pill form along with other ingredients. And that means the effects, and the potential side effects, are difficult to predict.

You can see some examples of pills I’ve tested and researched among my erectile dysfunction articles.

photo showing the difference between a sildamax and viagra pill

Your questions and experience

Do you have a question about any other combination not covered here?

Have you tried any of the above combinations, and are willing to describe your experience so other readers can learn from it?

Please leave an anonymous comment below to help grow this resource.

Further reading

In 2011, a group of researchers published a large review of combination therapy for erectile dysfunction.

If you’re interested in specific pharmaceutical drug treatment combinations, this journal entry might interest you.

And you might also like to read more premature ejaculation articles.


  1. What about overcoming loss of sensitivity from surgical procedures? We have discovered he has difficulty reaching orgasm and retaining an erection due to reduced sensitivity.

        • Hi again
          I’d say check with his doctor and then look into getting a pump. There is strong research evidence that they work well with some surgical related ED. The main issue is feeling weird using one, and some safety concerns. But as long as you can get past the less than sexy process, and use it safely, in my experience they are actually really effective.

  2. Great article, thanks for the advice and taking the time to put all this in one place. I have both pe and ed and it drives me crazy when something I do to help one makes the other worse. Best thing I found so far was viagra with a good thick condom (and maybe a glass of wine…).
    Even if it’s over quick the first time, the second is normally much longer. it’s crappy when you just met someone, but with my current long-term gf, it’s all good. Only problem is I get some side effects from viagra, even on low doses. so I try not to take it every time we have sex. I just use it as a backup for when my partner is really wanting some good action. thanks again

    • Hi Ryan
      I’m glad you liked the article! Thanks for sharing your experience too. I know what you mean about one treatment leading to other problems. The best example for me is delay sprays causing erection loss – not good at all!
      Viagra and a good condom can definitely help. And a bit of alcohol, despite the huge warning in the article, can also help with relaxation. Just be careful if you already get side effects with the viagra that the alcohol doesn’t make it worse.
      Perhaps you could talk to your doctor about trying Cialis instead, and see if that suits you better.

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