Premature Ejaculation Pills: An Overview Of The Main Types

priligy and viagra

In today’s fast-paced world we often need quick solutions to our problems. So it’s no surprise that men with premature ejaculation might be tempted by pills such as dapoxetine.

The problem though is that drugs usually come at a cost, with pills made to enhance sexual ability being no exception.

I’m not just talking about financial cost, although drugs like dapoxetine can certainly be expensive: in some countries, 3 pills will cost you over $100.

What I’m really talking about are the side-effects that these kinds of pills can cause, especially the prescription anti-depressants. In my view, something you take to improve your sex life shouldn’t give you problems like erectile dysfunction or decreased libido.

The purpose of this article isn’t to convince you that pills don’t work, because for many men they clearly do. What I want to do is give you my personal insight into the variety of pills available to help you weigh up the pros and cons carefully.

1. Paxil, Zoloft, Prozac and Anafranil


Anti-depressants are sometimes used off-label by doctors as a temporary premature ejaculation measure.

Off-label means that they aren’t officially recognized as a treatment, but doctors can use their discretion to prescribe them anyway.

There’s a wide range of anti-depressants, but there are 3 most commonly used to help premature ejaculation:

  • Paxil – the brand name for Paroxetine.
  • Prozac – the band name for Fluoxetine.
  • Zoloft or Lustral – the brand names for Sertraline.

These 3 are known as SSRIs, which stands for Selective Serotonin Reuptake Inhibitors. They can take between a week and 2 weeks to start working properly, at a lower dose than people who suffer from depression take.

A doctor would test them with you to find one which works and has the least side-effects. If none of them suit you, then they may try you on another kind:

  • Anafranil – the brand name for clomipramine.

Anafranil is known as a tricyclic anti-depressant and works in a different way. The hope is that it would do the trick if the others fail.

Issues with taking anti-depressants

There are 3 major problems I see with using anti-depressants as a premature ejaculation treatment:

  • You have to take them every day for them to work, even if you don’t have sex those days.
  • There’s a conceptual point to consider: do you really want to take anti-depressants if you don’t suffer from depression?
  • There’s a long list of potential side effects, some of which are serious and can have a negative effect on your sex life in other ways.

Just a few of the well-known side effects of these antidepressants include:

  1. Nausea and vomiting
  2. Diarrhea
  3. Headaches and dizziness
  4. Insomnia
  5. Appetite and weight changes
  6. Decreased libido
  7. Erectile dysfunction

The list is actually longer, but I think you probably get the point by now. Anti-depressants do help delay ejaculation, but you’re opening up a Pandora’s box of possible side effects.

Importantly, please don’t be tempted to buy these drugs online. You should discuss taking them with a medical professional first.

2. Priligy (the brand name for Dapoxetine)

30mg priligy tablets

Priligy was originally intended as another SSRI anti-depressant. Instead, it became the first official pill for premature ejaculation.

The main plus point is that your body processes it faster than other anti-depressants, so you only need to take it on the days you have sex.

It’s approved in many countries around the world, but not by the Food and Drugs Administration (FDA) in the United States yet. However, it is now available under the National Health Service (NHS) in the United Kingdom.

In testing I found it extended my lasting time by a couple of minutes on average. With that came some side effects such as headaches though. And in clinical trials, it’s been found that many men do experience at least mild side effects.

My opinion is that Priligy is okay, and works well for some men. But it brings with it other possible problems. If you’re interested in more details, have a look at my longer Dapoxetine review.

3. Tramadol

Tramadol capsules

Tramadol is a strong synthetic opioid analgesic which has been found in recent years to help delay ejaculation.

I rather unexpectedly found that tramadaol helps delay ejaculation when recovering from surgery 2 years ago. I found it added around 5 minutes to my lasting time on average, mirroring the results of several clinical trials investigating the effect.

However, I also experienced another effect that Tramadol is known to create – physical and psychological dependency. It is an opioid after all.

For this reason it’s unlikely to ever be licensed to be used as a mainstream premature ejaculation treatment, even though the dose for premature ejaculation is much lower than for pain.

As a premature ejaculation treatment just 25mg – 50mg is effective, but for severe pain you can take up to 400mg.

Nobody knows if using Tramadol is safe to use in the long-run for premature ejaculation. And to top it off here are just a few side effects you may experience:

  • Hallucinations
  • Breathing problems
  • Constipation
  • Nausea and vomiting
  • Headaches and dizziness
  • Fever-like symptoms

So my advice is to only consider tramadol if your doctor recommends it, and avoid buying it online from untrustworthy websites.

4. 5-HTP supplements

Some scientists believe that some men have premature ejaculation because of low serotonin levels. 5-HTP is a precursor to the hormone Serotonin, so taking supplements of 5-HTP is reported by some to help raise the serotonin levels in the body.

This is a premature ejaculation treatment, however, with little evidence to back it up.

If it does work, you don’t need a special premature ejaculation version made from 5-HTP. You can pick some up from a local health food store.

Or perhaps you could just try eating food high in Tryptophan, another precursor of Serotonin. Meat, eggs, fish, nuts and bananas are all good examples.

5-HTP is classed as a natural supplement, so pills sometimes pop up online that claim to help with premature ejaculation, and contain this as a principle ingredient.

5. Erectile dysfunction drugs: Viagra, Levitra and Cialis

image of the packet of viagra I tried

It’s possible that drugs known as phosphodiesterase inhibitors may be helpful for some men with premature ejaculation.

They’re better known, however, for helping men get or maintain erections. The following 3 are most commonly experimented with:

  • Viagra – the brand name for sildenafil.
  • Levitra – the brand name for vardenafil.
  • Cialis – the brand name for tadalafil.

A study in 2005 found some interesting results when men with premature ejaculation took Viagra. They found that although it increased lasting time, it wasn’t by much. But it did have the following effects:

  1. Men felt that they had better control.
  2. Men felt more confident in their sense of control.
  3. They were more sexually satisfied.
  4. They needed less time to rest between having sex the first and second time.

So although these drugs weren’t intended for ejaculation problems, they may help in different ways. Particularly useful is the shortening of the break men need – many men will last longer the second time around.

Doctors don’t usually recommend these drugs for premature ejaculation though. You may have to bring the idea up yourself in discussion. If you want to find out more about this, you might like to check out my viagra article.

6. Random pills sold online

There are a variety of sexual enhancement pills to be found online, often reportedly made from natural ingredients.

None that I know of have been tested in clinical trials, and most are unregulated because they are classed as supplements. That doesn’t mean they don’t work, just that there’s no research evidence for it.

It’s your choice if you want to experiment with any of these natural supplements. Just don’t be too surprised if you don’t get the results you’re looking for.

Your views

Have you tried any of these medications for premature ejaculation? What effect did they have? Please leave a comment below.

58 thoughts on “Premature Ejaculation Pills: An Overview Of The Main Types”

  1. I’ve tried basically everything to fix this problem, yesterday i tried a very high dose of dapoxetine taken 2 hours before and it was like i did not take it.
    I think i’m hopeless right now

    1. Hi Jack
      Sorry to hear you’re feeling that way. Dapoxetine won’t work for everyone, unfortunately. Have you tried any other techniques?

  2. Thank you excellent and informative article.

    How about using Anafranil 25mg with Cialis, any concern?.
    Would you please tell us about the new approved pills for PE

    1. Hi Adam
      You’re welcome. To be honest, I don’t know if it’s safe or not. I would definitely check that with your doctor. I do need to update this article – keep an eye out in the coming months!

    1. Hi Ka
      I don’t think it really matters which one you use. You could try both types to see which works for you.

  3. BobbyBrown

    Very small dose of suboxone sounds stupid but I have the same problem and I last an average of 3-5 min sometime less sometimes more but I take this sometimes around0.5-1mg and it at least 30min to 1hr depends on the size of the dose if u decide on this be VERY careful because there are alot of don’ts with this but my opinion nothing has helped me as much as this I’m very insecure about this issue it makes me sick to think about but I absolutely do not recommend this to everyone only people who are extremely disclipend without addictive personality it is an opiate blocked but mimics the effect I have the ability to control my self to Tue point where when I want to finish I do instead of fighting myself so hard not to do it I hope this might help someone because this is probably one of the most hush hush things men go thru and it’s really embarrassing so good luck

    1. Hi there
      Thanks for sharing your idea. However, I definitely wouldn’t recommend anyone use this drug to help with PE. When I worked in mental health, I saw many people who had become dependent on it, and struggled to get off it almost as much as the drug it was meant to be helping with in the first place!

  4. I tried a Tramadol 50mg and 50mg of viagra wow I could literally go for hours. Before I couldn’t last for a minute. but now I can go for hours with these 2 combined only use it once a week though so little side effects, only thing you get from viagra is a bad headache the next day

    1. Hi Ken
      I can well imagine how that combination would have a powerful effect. I’d be careful though, as both can have an effect on the heart, not just the headache. I haven’t seen it advised in any medical source that it’s a safe combination, and I’d defo. be cautious using them together.

  5. Mike Petrow

    I suffer from premature ejaculation. Its something that makes me feel like a failure in life. I’ve tried a lot of cures but I can’t hold out. Anyone have a suggestion? And it’s not because the guys are hot that I’m with.It’s me.
    Feeling bad.

    1. Hi Mike
      Sorry to hear you’re feeling that way because of PE. But believe me, you’re not a failure because of it! In fact, just by looking it up online, you’re already taking important steps towards dealing with it. You should be proud that you’re willing to face your problems and deal with them.
      Anyway, motivational pep talk aside, my advice would be to take a really good look around this site. I’ve written tons of articles about PE, with as much advice as I can think of. I’d be surprised if you’ve tried everything here!
      Stay positive!

Leave a Comment

Your email address will not be published.