Premature Ejaculation Pills: An Overview Of The Main Types

priligy and viagra

In today’s fast-paced world we often need quick solutions to our problems. So it’s no surprise that men with premature ejaculation might be tempted by pills such as dapoxetine.

The problem though is that drugs usually come at a cost, with pills made to enhance sexual ability being no exception.

I’m not just talking about financial cost, although drugs like dapoxetine can certainly be expensive: in some countries, 3 pills will cost you over $100.

What I’m really talking about are the side-effects that these kinds of pills can cause, especially the prescription anti-depressants. In my view, something you take to improve your sex life shouldn’t give you problems like erectile dysfunction or decreased libido.

The purpose of this article isn’t to convince you that pills don’t work, because for many men they clearly do. What I want to do is give you my personal insight into the variety of pills available to help you weigh up the pros and cons carefully.

1. Paxil, Zoloft, Prozac and Anafranil


Anti-depressants are sometimes used off-label by doctors as a temporary premature ejaculation measure.

Off-label means that they aren’t officially recognized as a treatment, but doctors can use their discretion to prescribe them anyway.

There’s a wide range of anti-depressants, but there are 3 most commonly used to help premature ejaculation:

  • Paxil – the brand name for Paroxetine.
  • Prozac – the band name for Fluoxetine.
  • Zoloft or Lustral – the brand names for Sertraline.

These 3 are known as SSRIs, which stands for Selective Serotonin Reuptake Inhibitors. They can take between a week and 2 weeks to start working properly, at a lower dose than people who suffer from depression take.

A doctor would test them with you to find one which works and has the least side-effects. If none of them suit you, then they may try you on another kind:

  • Anafranil – the brand name for clomipramine.

Anafranil is known as a tricyclic anti-depressant and works in a different way. The hope is that it would do the trick if the others fail.

Issues with taking anti-depressants

There are 3 major problems I see with using anti-depressants as a premature ejaculation treatment:

  • You have to take them every day for them to work, even if you don’t have sex those days.
  • There’s a conceptual point to consider: do you really want to take anti-depressants if you don’t suffer from depression?
  • There’s a long list of potential side effects, some of which are serious and can have a negative effect on your sex life in other ways.

Just a few of the well-known side effects of these antidepressants include:

  1. Nausea and vomiting
  2. Diarrhea
  3. Headaches and dizziness
  4. Insomnia
  5. Appetite and weight changes
  6. Decreased libido
  7. Erectile dysfunction

The list is actually longer, but I think you probably get the point by now. Anti-depressants do help delay ejaculation, but you’re opening up a Pandora’s box of possible side effects.

Importantly, please don’t be tempted to buy these drugs online. You should discuss taking them with a medical professional first.

2. Priligy (the brand name for Dapoxetine)

30mg priligy tablets

Priligy was originally intended as another SSRI anti-depressant. Instead, it became the first official pill for premature ejaculation.

The main plus point is that your body processes it faster than other anti-depressants, so you only need to take it on the days you have sex.

It’s approved in many countries around the world, but not by the Food and Drugs Administration (FDA) in the United States yet. However, it is now available under the National Health Service (NHS) in the United Kingdom.

In testing I found it extended my lasting time by a couple of minutes on average. With that came some side effects such as headaches though. And in clinical trials, it’s been found that many men do experience at least mild side effects.

My opinion is that Priligy is okay, and works well for some men. But it brings with it other possible problems. If you’re interested in more details, have a look at my longer Dapoxetine review.

3. Tramadol

Tramadol capsules

Tramadol is a strong synthetic opioid analgesic which has been found in recent years to help delay ejaculation.

I rather unexpectedly found that tramadaol helps delay ejaculation when recovering from surgery 2 years ago. I found it added around 5 minutes to my lasting time on average, mirroring the results of several clinical trials investigating the effect.

However, I also experienced another effect that Tramadol is known to create – physical and psychological dependency. It is an opioid after all.

For this reason it’s unlikely to ever be licensed to be used as a mainstream premature ejaculation treatment, even though the dose for premature ejaculation is much lower than for pain.

As a premature ejaculation treatment just 25mg – 50mg is effective, but for severe pain you can take up to 400mg.

Nobody knows if using Tramadol is safe to use in the long-run for premature ejaculation. And to top it off here are just a few side effects you may experience:

  • Hallucinations
  • Breathing problems
  • Constipation
  • Nausea and vomiting
  • Headaches and dizziness
  • Fever-like symptoms

So my advice is to only consider tramadol if your doctor recommends it, and avoid buying it online from untrustworthy websites.

4. 5-HTP supplements

Some scientists believe that some men have premature ejaculation because of low serotonin levels. 5-HTP is a precursor to the hormone Serotonin, so taking supplements of 5-HTP is reported by some to help raise the serotonin levels in the body.

This is a premature ejaculation treatment, however, with little evidence to back it up.

If it does work, you don’t need a special premature ejaculation version made from 5-HTP. You can pick some up from a local health food store.

Or perhaps you could just try eating food high in Tryptophan, another precursor of Serotonin. Meat, eggs, fish, nuts and bananas are all good examples.

5-HTP is classed as a natural supplement, so pills sometimes pop up online that claim to help with premature ejaculation, and contain this as a principle ingredient.

5. Erectile dysfunction drugs: Viagra, Levitra and Cialis

image of the packet of viagra I tried

It’s possible that drugs known as phosphodiesterase inhibitors may be helpful for some men with premature ejaculation.

They’re better known, however, for helping men get or maintain erections. The following 3 are most commonly experimented with:

  • Viagra – the brand name for sildenafil.
  • Levitra – the brand name for vardenafil.
  • Cialis – the brand name for tadalafil.

A study in 2005 found some interesting results when men with premature ejaculation took Viagra. They found that although it increased lasting time, it wasn’t by much. But it did have the following effects:

  1. Men felt that they had better control.
  2. Men felt more confident in their sense of control.
  3. They were more sexually satisfied.
  4. They needed less time to rest between having sex the first and second time.

So although these drugs weren’t intended for ejaculation problems, they may help in different ways. Particularly useful is the shortening of the break men need – many men will last longer the second time around.

Doctors don’t usually recommend these drugs for premature ejaculation though. You may have to bring the idea up yourself in discussion. If you want to find out more about this, you might like to check out my viagra article.

6. Random pills sold online

There are a variety of sexual enhancement pills to be found online, often reportedly made from natural ingredients.

None that I know of have been tested in clinical trials, and most are unregulated because they are classed as supplements. That doesn’t mean they don’t work, just that there’s no research evidence for it.

It’s your choice if you want to experiment with any of these natural supplements. Just don’t be too surprised if you don’t get the results you’re looking for.

Your views

Have you tried any of these medications for premature ejaculation? What effect did they have? Please leave a comment below.

58 thoughts on “Premature Ejaculation Pills: An Overview Of The Main Types”

  1. I’ve tried basically everything to fix this problem, yesterday i tried a very high dose of dapoxetine taken 2 hours before and it was like i did not take it.
    I think i’m hopeless right now

    1. Hi Jack
      Sorry to hear you’re feeling that way. Dapoxetine won’t work for everyone, unfortunately. Have you tried any other techniques?

  2. Thank you excellent and informative article.

    How about using Anafranil 25mg with Cialis, any concern?.
    Would you please tell us about the new approved pills for PE

    1. Hi Adam
      You’re welcome. To be honest, I don’t know if it’s safe or not. I would definitely check that with your doctor. I do need to update this article – keep an eye out in the coming months!

    1. Hi Ka
      I don’t think it really matters which one you use. You could try both types to see which works for you.

  3. BobbyBrown

    Very small dose of suboxone sounds stupid but I have the same problem and I last an average of 3-5 min sometime less sometimes more but I take this sometimes around0.5-1mg and it at least 30min to 1hr depends on the size of the dose if u decide on this be VERY careful because there are alot of don’ts with this but my opinion nothing has helped me as much as this I’m very insecure about this issue it makes me sick to think about but I absolutely do not recommend this to everyone only people who are extremely disclipend without addictive personality it is an opiate blocked but mimics the effect I have the ability to control my self to Tue point where when I want to finish I do instead of fighting myself so hard not to do it I hope this might help someone because this is probably one of the most hush hush things men go thru and it’s really embarrassing so good luck

    1. Hi there
      Thanks for sharing your idea. However, I definitely wouldn’t recommend anyone use this drug to help with PE. When I worked in mental health, I saw many people who had become dependent on it, and struggled to get off it almost as much as the drug it was meant to be helping with in the first place!

  4. I tried a Tramadol 50mg and 50mg of viagra wow I could literally go for hours. Before I couldn’t last for a minute. but now I can go for hours with these 2 combined only use it once a week though so little side effects, only thing you get from viagra is a bad headache the next day

    1. Hi Ken
      I can well imagine how that combination would have a powerful effect. I’d be careful though, as both can have an effect on the heart, not just the headache. I haven’t seen it advised in any medical source that it’s a safe combination, and I’d defo. be cautious using them together.

  5. Mike Petrow

    I suffer from premature ejaculation. Its something that makes me feel like a failure in life. I’ve tried a lot of cures but I can’t hold out. Anyone have a suggestion? And it’s not because the guys are hot that I’m with.It’s me.
    Feeling bad.

    1. Hi Mike
      Sorry to hear you’re feeling that way because of PE. But believe me, you’re not a failure because of it! In fact, just by looking it up online, you’re already taking important steps towards dealing with it. You should be proud that you’re willing to face your problems and deal with them.
      Anyway, motivational pep talk aside, my advice would be to take a really good look around this site. I’ve written tons of articles about PE, with as much advice as I can think of. I’d be surprised if you’ve tried everything here!
      Stay positive!

  6. Ethan,
    You did not mention Kamagra from India. It is described as medication for PE. Does it have the same exact ingredients as Viagra? I have looked for an answer to this question and so far have not seen it addressed.

  7. I like this article. The problem with dapoxitine is that should be taken just before each sexual intercourse, which is drawback for this medication.
    So, my question is, for how long shall a person with PE take Prozac ? Is it temporarily or permanent ?

    1. Hi Tim
      To be honest, the fact that you only take it when you have sex is one of the main positives. It means you don’t need to take something like prozac every single day, which would have a bigger impact on your brain chemistry and higher risk of side effects.

  8. Please my brother am suffering this since my mature age have never long pass 30 seconds i need pills that wil kill it

    1. Hi escalade
      If you really want to try a pill for it, then the best one I’ve tried myself is dapoxetine. But I’d also recommend trying a delay spray and the behavioral techniques too.

    1. Hi Omar
      That’s a good question, and not easy to answer. It depends on the guy and how well he responds to a particular pill – the same pill can have very different effects for different guys. It also depends on the side effects, what you experience personally and if you can tolerate them. I think if it’s something you’re interested in, the best thing is to speak to your doctor. You can also read my article about pe treatment research for information about what clinical trials have shown.

  9. My doc recommended I try anti-depressants, but I didn’t like the sound of some of the side effects. Can desensitizing creams give the same results? cheers

    1. Hi Len
      I understand completely – the side effects can seem quite worrying. I think that delay sprays etc can help equally well, if not better for some guys. Whether it’s the right choice of treatment for you or not won’t become clear until you actually try it though.

  10. Would you recommend taking viagra for pe if I don’t have erection problems?

    1. Hi Brendon
      Good question. I think if you can find something else that works, it’s probably better. But technically, viagra could help you last longer – or be ready again sooner – even if you don’t have erectile dysfunction. You can find out more about how it works in that way in my viagra review.

        1. Hi Jay
          To be honest, I think there’s still a lack of clear information about the long-term side effects. If you read articles like the one on, you’ll find lists of suggested long-term effects for some men. But then there are research studies like this one in 2007 that show no long-term effects and that most men continued taking it for several years without serious problems.
          I think that maybe more time is needed before scientists are completely sure of the risk of long-term effects. So for now, the best thing is probably to use it carefully and consult your doctor as to whether it’s likely to be safe for you.

  11. Hi Ethan
    First of all thanx for very valuable article.
    I am 28 year old . Suffering from pe. I discharged within a minute while mastrubating I m suffering from 14/15 years. What is the best way to treat PE

    1. Hi Jitendra
      You’re welcome – I’m glad you found the article useful. My personal belief is that it’s best to do so with natural techniques, but also perhaps use a desensitizing spray in the short-term if you want something that will provide some immediate help. I recommend checking out my article about choosing the best premature ejaculation treatment. I discuss the main options in that article, so you should find it helpful.

  12. Hi Ethan, first of all, id like to thank you for your fantastic article, it is more than helpful to me after ages of searching on the internet.
    I’d like to ask you if its ok to use both tramadol and viagra since i’m suffering already 15 years with both erection dysfunction and PE, it has been recommended from friends of mine, i use viagra but with no effect on PE.
    Thanks again

    1. Hi Mody
      Thanks for the compliment – I’m glad you found the article useful. I would be careful mixing viagra and tramadol and only do it after discussing with your doctor.

  13. Hi Sam
    That’s good to hear! It’s always useful to hear from guys who had a positive experience with a treatment.

  14. Mitkumar

    hi…My Name is Mitkumar…i’m 25 years old….i have a very big problem is Early Dysfunction and its cause only that i have a very less fore skin on the tip of penis and my my penis is so sensitive so after the entering in vagina only 2 Minuit i had been discharged so my partner got very upset due this mine problems occurred every time….so please help me…and my penis foreskin is also less i don’t know why but will i grow foreskin again???? please help me cause now my married life would be the end of brake up….please help me……and suggest me some pill and how it will work for stop PE or ED……….

    1. Hi Mitkumar
      First of all, no you won’t grow new foreskin if you have a shorter one. Secondly, perhaps you might benefit from using a thicker condom than usual, or even a delay condom. This can help with the sensitivity. Either that or a spray. I can understand your desire for a pill, but unfortunately there really aren’t any which are amazing. You could try dapoxetine, but that’s unlikely to add more than 2-3 minutes. Alternatively, your doctor can prescribe you anti-depressants which do work for some guys. But they come with all kinds of risks. My advice would be to try a condom and/or spray first. If that doesn’t work, you could try dapoxetine or ask for your doctor’s help.

    2. Hi,I had same problem like you.. But I do sex 2 or 3 time a month. Ok how I recover from that problem just going to share with you. First after meeting with doctors I m started to take paroxetine which is antidepressants pills and with that on sex day I add Viagra.. So on first sex I do quickly pe but in second time sex I can perform well. But please remind that antidepressants pills has some side effects.. Good luck

  15. Just discovered this site today.. Great site indeed and great job you’re doing..Ethan. Really helping out. From comments and your diligent responses have already enlightened me on d drugs to try and those not to try.
    Thanks and keep it up.

  16. Ethan, great site. Did you experience any side effects from Tramadol? Did you feel addicted to it? Did it make you less alert, groggy, etc and lessen libido? Did you try out any PDE5 (like Viagra)? If yes, how did it work for you? Thanks.

    1. Hi Robby
      Thanks for your comment and compliment about the site – much appreciated!
      Yes, I definitely felt less alert when I took tramadol, but I don’t recall a libido problem. I actually tried viagra recently, as I was visiting Brazil where you can buy it in any chemist, unbelievably. I’m planning on writing about it soon, but yes, it definitely helped me both keep an erection for longer (and was harder too) and last longer. Apart from some headaches it was pretty awesome really.

      1. Hi guys. Great site indeed. Also am suffering from PE. Now..Ethan…what worked great viagra or tramadol? I have read a lot of scientific research on PE and believe dapoxetin 60 mg 30-60 minutes before sex apparently double or triple the time to ejaculation. The superiority of Dapoxetin is however is in its on demand status and body metabolize it and out of your body quickly. All other drugs and antidepressants for PE remain in the body and you need to take them daily as if you are suffering from depression and has numerous side effects. Regret Dapoxetin still not approved by FDA but you can buy it in europe or Asia. Lots of so called on line drug stores sell dapixetin but who knows what tgey are selling. In USA you can ask your doctor for paroxtine 20 mg which has same formula as dapoxetin but is not on demand and you must take it daily. In one study paroxetin was far more superior than dapoxetin for PE. But again who wants to take it daily.

        1. Hi Sam
          Thanks for your comment, and I’m glad you liked the site – that’s always nice to hear. That’s actually a very good question, and not one I’d thought about until reading your comment. To be honest, it’s kind of impossible to answer unfortunately. I took the tramadol ages ago and the Viagra very recently. And I have much better control now than I did at the time I took the tramadol.

          If I think about it just in terms of the difference it made to me at the time, I’d say tramadol had a more powerful effect. But that’s because my lasting time wasn’t that great to start with, so for me it was kind of a miracle.

          With the Viagra, I’m more used to lasting longer naturally these days, so although I felt like I had great control, I do sometimes have that feeling anyway. But there’s no doubt it gave me a good boost.

          So in some ways, I’d say both had a very positive effect on my stamina. However, the Viagra also gave me serious erections, whereas the only other effects of the tramadol are negative.

          I also agree with what you say about not wanting to take pills on an on-going basis. The idea of taking anti-depressants for PE is terrible in my eyes. Dapoxetine is definitely better as you take it on demand.


  17. Abdullah

    Hi. I am 32 years old, married and have a 17 months old boy. I have been married for three and half year now. Before marriage, I never had a p.e problem I used to last for a good 8 to 12 minutes after entering the Vigina. But now I sometimes last a 1 or sometimes I ejaculate a few seconds after I enter the Vagina. I am thinking the reason for this is the past. I was an alcoholic for 10 years, drinking one or two bottles daily and used to smoke 15 to 30 cigarettes of Hashish daily. So I am thinking the reason I used to last long and now ejaculate tools soon is the same. Plus watching porn and ejaculating quickly to finish up did not help either.
    I have tried delay sprays, delay condoms, herbal medicine but nothing seems to work. I have tried the stop and start technique but the only thing I got out of it is that I can stop and restart my pee lol….
    So now I was told that a low dose of Tramadol and taking it alongside cialis about 1 to 2 hours before sex can help you last longer. I wanted to know what are your thoughts about all this.

    1. Hi Abdullah
      Thanks for your comment. To be honest, it’s possible that if you had sex before when drinking or smoking, that may have been numbing your sensitivity, so perhaps the problem has always been there. If not, then maybe it’s because you don’t have sex so often nowadays, or you just haven’t been doing the right things to keep yourself on a good arousal level.
      I don’t know if those pills will help – they might or might not. You just don’t know until you try them.
      My advice would be to also look into trying natural techniques. It could be that all you need is some instruction and ideas for keeping yourself calm. The start stop technique usually helps though. How long have you practiced it for?

  18. Abdul Kharim Eugenio

    I want to buy premature ejaculation medicine but I don’t know How to order, I’m here now Jizan K.S.A.
    Abdul Kharim

    1. Hi Abdul
      i don’t have any ordering information for medication because I only do reviews, amd to be honest, I don’t really recommend many pills so I haven’t said where to get them from a lot of the time. So you would have to look on the internet for a company that ships to you.

  19. Which medical and where available Priligy pills ?
    How to find in India ?

    1. Hi Bhushan
      Thanks for your comment. I’m not sure where’s the best place to get it in India. You’d need to do some research to find a pharmacy you feel you can trust.

  20. Can paxil cure PE for good if taken on a daily basis for a period of 12 weeks for instance?

    1. Hi Josh
      Even if it helps you during the time you take it, once you stop taking it the problem might return, unless the psychological boost from lasting longer has a more permanent effect. But I doubt it will cure it.

  21. You are a real genius & a complete professional, I might try tramadol, hope it help me solved this ‘acquired’ dreaded problem permanently, thanks so much.

  22. Hi
    I read it all , i’m using now anafranil and it is wonderful
    But it have 2 problem
    1- headaches
    2- when i eat this for example @ 8:00 pm It will start for safe 1:00 am & between this period i feel my thinking not clear
    3- the important thing is that i should eat with it something that make my … Have good stand up . Its happened with me one time when i eat it my … does not stand up

    pls i need some thing perfect for long time

    1. Hi Ayoub
      So basically the anafranil is giving you headaches and stopping you from getting an erection? My advice would be to speak to your doctor about this and see if they can offer an alternative which doesn’t have those side effects.

  23. Michael

    Thanks for this helpful article. After reading it, I think I’m gonna try the natural ideas first instead of getting into pills or anything else. M

    1. Hi Michael,
      Glad you found it helpful, and I think that’s a very sensible choice. All the best with it!

  24. Michael

    Thanks for your informative article. I’ve been wondering what I can use to improve my lasting time, and so naturally though there would be a pill for it. There is for most things these days! But after reading this, I will definitely think about my options.

    1. No problem Michael. I’m very happy you found it helpful.
      All the best and I hope you find something which works for you.

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