Premature Ejaculation Pills

In today’s fast paced world we often need quick solutions to our problems. So it’s no surprise that many guys are tempted by premature ejaculation pills such as Dapoxetine.

The problem though is that pharmaceuticals often come at a cost, with pills made to enhance sexual ability being no exception.

I’m not just talking about financial cost, although drugs like Priligy can certainly be expensive: in some countries 3 pills will cost you over $100.

What I’m really talking about are the side-effects that these kind of pills can cause, especially the prescription anti-depressants. In my view, something you take to improve your sex life shouldn’t give you problems like erectile dysfunction or decreased libido.

The purpose of this article isn’t to convince you that pills don’t work, because for many guys they clearly do. What I want to do is give you an insight into the variety of pills available, and to help you weigh up the pros and cons carefully.


1. Paxil, Zoloft, Prozac and Anafranil

prozac pillsAnti-depressants are sometimes used off-label by doctors as a temporary premature ejaculation measure.

Off-label means that they aren’t officially recognized as a treatment, but doctors can use their discretion to prescribe them anyway.

There’s a wide range of anti-depressants, but there are 3 most commonly used to help premature ejaculation:

  • Paxil – the brand name for Paroxetine.
  • Prozac – the band name for Fluoxetine.
  • Zoloft or Lustral – the brand names for Sertaline.

These 3 are known as SSRIs, which stands for Selective Serotonin Reuptake Inhibitors. They can take between a week and 2 weeks to start working properly, at a lower dose than people who suffer from depression take.

A doctor would test them with you to find one which works and has the least side-effects. If none of them suit you, then they may try you on another kind:

  • Anafranil – the brand name for clomipramine.

Anafranil is known as a tricylic anti-depressant and works in a different way. The hope being that it would do the trick where the others failed.

Issues with taking anti-depressants

There are 3 major problems I see with using anti-depressants as a premature ejaculation treatment:

  • You have to take them every day on a permanent basis. Some sources say they may work if you only take them a few hours before you have sex. But guys often say they end up having to take them daily.
  • There’s a conceptual point to consider: do you really want to take anti-depressants if you don’t suffer from depression?
  • There’s a long list of potential side effects, some of which are serious and can have a negative effect on your sex life in other ways.

Just a few of the well-known side effects of these anti-depressants include:

  1. Nausea and vomiting
  2. Diarrhea
  3. Headaches and dizziness
  4. Insomnia
  5. Appetite and weight changes
  6. Decreased libido
  7. Erectile dysfunction

The list is actually much longer, but I think you probably get the point by now. Anti-depressants do help delay ejaculation, but you’re opening up a Pandora’s box of possible side effects.

Importantly, please don’t be tempted to buy these drugs online or illegally. You should discuss taking them with a medical professional first.

2. Priligy (the brand name for Dapoxetine)

30mg priligy tabletsPriligy was originally intended as another SSRI anti-depressant. Instead it became the first official premature ejaculation pill.

The main plus point is that your body processes it faster than other anti-depressants, so you only need to take it on the days you have sex.

It’s approved in many countries around the world, but not by the Food and Drugs Administration (FDA) in the United States yet. And it’s not available under the National Health Service (NHS) in the United Kingdom.

In testing I found it extended my lasting time by between 2 and 4 minutes on average. With that came some side effects such as headaches though. And in clinical trials it’s been that many men do experience at least mild side effects.

My opinion is that Priligy is perhaps a bit over-hyped and over-priced. Yes it works, but not that effectively and brings with it other possible problems. If you’re interested in more details about this drug, have a look at my longer Dapoxetine review.

Other pills for premature ejaculation

3. Tramadol

50 mg tramadol pillsTramadol is a strong synthetic opioid analgesic which has been found in recent years to help delay ejaculation.

I rather unexpectedly found that tramadaol helps delay ejaculation when recovering from surgery 2 years ago. I found it added around 5 minutes to my lasting time on average, mirroring the results of several clinical trials investigating the effect.

However, I also experienced another effect that Tramadol is known to create – physical and psychological dependency. It is an opioid after all.

For this reason it’s unlikely to ever be licensed to be used as a mainstream premature ejaculation treatment, even though the dose for premature ejaculation is much lower than for pain.

As a premature ejaculation treatment just 25mg – 50mg is effective, but for severe pain you can take up to 400mg.

Nobody knows if using Tramadol is safe to use in the long-run for premature ejaculation. And to top it off here are just a few side effects you may experience:

  • Hallucinations
  • Breathing problems
  • Constipation
  • Nausea and vomiting
  • Headaches and dizziness
  • Fever-like symptoms

So my advice is to only consider tramadol if your doctor recommends it, and avoid buying it online from untrustworthy websites.

4. 5-HTP supplements

5htp pillsScientists believe that some men have premature ejaculation because of low serotonin levels. 5-HTP is a precursor to the hormone Serotonin, so taking supplements of 5-HTP can help raise the serotonin levels in the body.

This is a premature ejaculation treatment, however, with little evidence to back it up.

If it does work you don’t need a special premature ejaculation version made from 5-HTP. You can pick some up from a local health food store.

Or you could just try eating food high in Tryptophan, another precursor of Serotonin. Meat, eggs, fish, nuts and bananas are all good examples.

5-HTP is classed as a natural supplement and so it’s relatively easy to manufacture delay pills without needing FDA approval. Because of that you’ll find 5-HTP in various pills for premature ejaculation sold online.

5. Erectile dysfunction drugs: Viagra, Levitra and Cialis

image of the packet of viagra I triedIt’s possible that drugs known as phosphodiesterase inhibitors may be helpful for guys with premature ejaculation.

They’re better known, however, for helping guys get or maintain erections. The following 3 are most commonly experimented with:

  • Viagra – the brand name for sildenafil.
  • Levitra – the brand name for vardenafil.
  • Cialis – the brand name for tadalafil.

A study in 2005 found some interesting results when guys with premature ejaculation took Viagra. They found that although it increased lasting time, it wasn’t by much. But it did have the following effects:

  1. Men felt that they had better control.
  2. Men felt more confident in their sense of control.
  3. They were more sexually satisfied.
  4. They needed less time to rest between having sex the first and second time.

So although these drugs aren’t designed as delay pills, they may help in different ways. Particularly useful is the shortening of the break men need. It’s well known that guys tend to last longer the second time round. So if that second time occurs sooner, it’s likely both partners will be happier.

Doctors don’t usually recommend these drugs for premature ejaculation though. You may have to bring the idea up yourself in discussion. If you want to find out more about this, you might like to check out my Viagra review.

6. Other delay pills

ejacutrol delay pillsThere are a variety of other premature ejaculation pills to be found online, often made from several natural ingredients. Here are 4 examples:

A) Ejacutrol – contains 5 natural ingredients:

  • Schisandra Chinensis
  • Mucuna Pruriens
  • Cistanche Deserticola
  • L-arginine
  • Gotu Kola

B) Delay – made by the company with the name ‘Delay’. Contains the extracts of 7 natural ingredient:

  • Cnidium monnieri
  • Cuscuta chinensis
  • Griffonia simplicifolia
  • Passiflora incarnata
  • Pyridoxine
  • Elletaria cardamomum
  • Piper nigrum

C) Duramale – contains 7 natural ingredients:

  • Indian Gooseberry
  • Elephant Creeper
  • Indian Ginseng
  • Pellitory
  • Nutmeg
  • Tailed
  • Clove

D) Magnumer Stamina – made by Biprosper Labs. Contains 11 ingredients, mostly natural. Note that it contains Gelatin, so isn’t suitable for vegetarians or vegans.

  • Ginkco Biloba
  • Phosphatidylserine Complex
  • Acetyl-L-Carnitine
  • St. John’s Wart
  • Glutamine
  • DMAE Bitartrate
  • Bacopin
  • Vinpocetine
  • Silica
  • Magnesium Stearate
  • Gelatin

None of these delay pills have been tested in clinical trials, nor have they been approved in any country as far as I’m aware. That doesn’t mean they don’t work, just that there’s no research evidence for it.

It’s your choice if you want to experiment with any of these natural supplements. Just don’t be too surprised if you don’t get the results you’re looking for.


As you can see then there’s an extensive range of pills which are claimed to help guys with premature ejaculation. Some of these claims are based on scientific evidence, but others are more spurious since they don’t need medical approval.

It’s a personal choice to take medication or not, and a difficult one for guys who are desperate to end their suffering in bed. Whatever you decide to do, do it safely and with medical guidance if possible. And make sure you check out every possible option for dealing with premature ejaculation at the same time.


My first choice treatment for dealing with premature ejaculation is through natural techniques, but I can understand if you need something which will help you out immediately.

If you do need something which will help you straight away, I recommend trying out desensitizing sprays before taking any pills.

And if you’re interested in dealing with the problem naturally, there are some good ejaculation control guides which teach you how to control your ejaculation on a lasting basis.


+ Add Comment
  1. hi my problem is different. I don’t ejaculate sometimes during sex, though sometimes i do. What can do to ejaculate each time i have sex?

  2. I’ve tried basically everything to fix this problem, yesterday i tried a very high dose of dapoxetine taken 2 hours before and it was like i did not take it.
    I think i’m hopeless right now

    1. Ethan Green

      Hi Jack
      Sorry to hear you’re feeling that way. Dapoxetine won’t work for everyone, unfortunately. Have you tried any other techniques?

  3. Thank you excellent and informative article.

    How about using Anafranil 25mg with Cialis, any concern?.
    Would you please tell us about the new approved pills for PE

    1. Ethan Green

      Hi Adam
      You’re welcome. To be honest, I don’t know if it’s safe or not. I would definitely check that with your doctor. I do need to update this article – keep an eye out in the coming months!

    1. Ethan Green

      Hi Ka
      I don’t think it really matters which one you use. You could try both types to see which works for you.

  4. BobbyBrown

    Very small dose of suboxone sounds stupid but I have the same problem and I last an average of 3-5 min sometime less sometimes more but I take this sometimes around0.5-1mg and it at least 30min to 1hr depends on the size of the dose if u decide on this be VERY careful because there are alot of don’ts with this but my opinion nothing has helped me as much as this I’m very insecure about this issue it makes me sick to think about but I absolutely do not recommend this to everyone only people who are extremely disclipend without addictive personality it is an opiate blocked but mimics the effect I have the ability to control my self to Tue point where when I want to finish I do instead of fighting myself so hard not to do it I hope this might help someone because this is probably one of the most hush hush things men go thru and it’s really embarrassing so good luck

    1. Ethan Green

      Hi there
      Thanks for sharing your idea. However, I definitely wouldn’t recommend anyone use this drug to help with PE. When I worked in mental health, I saw many people who had become dependent on it, and struggled to get off it almost as much as the drug it was meant to be helping with in the first place!

  5. I tried a Tramadol 50mg and 50mg of viagra wow I could literally fuck for hours. Before I couldn’t fuck for a minute. but now I can fuck for hours with these 2 combined only use it once a week though so little side effects, only thing you get from viagra is a bad ass headache the next day

    1. Ethan Green

      Hi Ken
      I can well imagine how that combination would have a powerful effect. I’d be careful though, as both can have an effect on the heart, not just the headache. I haven’t seen it advised in any medical source that it’s a safe combination, and I’d defo. be cautious using them together.

  6. Mike Petrow

    I suffer from premature ejaculation. I’ts something that makes me feel like a failure in life. I’ve tried a lot of cures but I can’t hold out. Any one have a suggestion? And it’s not because the guys are hot that i’m with. It’s me.

    Feeling bad.

    Thanks. Michael Petrow Venice FL

    1. Ethan Green

      Hi Mike
      Sorry to hear you’re feeling that way because of PE. But believe me, you’re not a failure because of it! In fact, just by looking it up online, you’re already taking important steps towards dealing with it. You should be proud that you’re willing to face your problems and deal with them.
      Anyway, motivational pep talk aside, my advice would be to take a really good look around this site. I’ve written tons of articles about PE, with as much advice as I can think of. I’d be surprised if you’ve tried everything here!
      Stay positive!

  7. Ethan,
    You did not mention Kamagra from India. It is described as medication for PE. Does it have the same exact ingredients as Viagra? I have looked for an answer to this question and so far have not seen it addressed.

    1. Ethan Green

      Hi Doug
      I haven’t tried it myself yet, but will see if I can get hold of it at some point and add a review.

  8. I like this article. The problem with dapoxitine is that should be taken just before each sexual intercourse, which is drawback for this medication.
    So, my question is, for how long shall a person with PE take Prozac ? Is it temporarily or permanent ?

    1. Ethan Green

      Hi Tim
      To be honest, the fact that you only take it when you have sex is one of the main positives. It means you don’t need to take something like prozac every single day, which would have a bigger impact on your brain chemistry and higher risk of side effects.

    1. Ethan Green

      Why would you want to do that Ricky? I personally wouldn’t want to picture someone I don’t like while I’m having sex. It just takes away from the experience!

  9. Please my brother am suffering this since my mature age have never long pass 30 seconds i need pills that wil kill it

    1. Ethan Green

      Hi escalade
      If you really want to try a pill for it, then the best one I’ve tried myself is dapoxetine. But I’d also recommend trying a delay spray and the behavioral techniques too.

    2. Hi,I m 35 years old person. I got v big problem of PE.. But after taking seroxat daily and sex day I take Viagra as well.. And I feel great.. In sex time..

    1. Ethan Green

      Hi Omar
      That’s a good question, and not easy to answer. It depends on the guy and how well he responds to a particular pill – the same pill can have very different effects for different guys. It also depends on the side effects, what you experience personally and if you can tolerate them. I think if it’s something you’re interested in, the best thing is to speak to your doctor. You can also read my article about pe treatment research for information about what clinical trials have shown.

  10. My doc recommended I try anti-depressants, but I didn’t like the sound of some of the side effects. Can desensitizing creams give the same results? cheers

    1. Ethan Green

      Hi Len
      I understand completely – the side effects can seem quite worrying. I think that delay sprays etc can help equally well, if not better for some guys. Whether it’s the right choice of treatment for you or not won’t become clear until you actually try it though. If you’d like to know more about some of the research that’s gone into these treatments, have a look at my latest article about premature ejaculation treatment research.

  11. Would you recommend taking viagra for pe if I don’t have erection problems?

    1. Ethan Green

      Hi Brendon
      Good question. I think if you can find something else that works, it’s probably better. But technically, viagra could help you last longer – or be ready again sooner – even if you don’t have erectile dysfunction. You can find out more about how it works in that way in my viagra review.

        1. Ethan Green

          Hi Jay
          To be honest, I think there’s still a lack of clear information about the long-term side effects. If you read articles like the one on, you’ll find lists of suggested long-term effects for some men. But then there are research studies like this one in 2007 that show no long-term effects and that most men continued taking it for several years without serious problems.
          I think that maybe more time is needed before scientists are completely sure of the risk of long-term effects. So for now, the best thing is probably to use it carefully and consult your doctor as to whether it’s likely to be safe for you.

  12. Hi Ethan
    First of all thanx for very valuable article.
    I am 28 year old . Suffering from pe. I discharged within a minute while mastrubating I m suffering from 14/15 years. What is the best way to treat PE

    1. Ethan Green

      Hi Jitendra
      You’re welcome – I’m glad you found the article useful. My personal belief is that it’s best to do so with natural techniques, but also perhaps use a desensitizing spray in the short-term if you want something that will provide some immediate help. I recommend checking out my article about choosing the best premature ejaculation treatment. I discuss the main options in that article, so you should find it helpful.

  13. Hi Ethan, first of all i, d like to thank you for your fantastic artikel, it is more than helpfull to me after ages of searching on internet,
    I.d like to ask you if it,s ok to use both tramadil and viagra since i.m suffering already 15 years with both erection dysfunction and PE, it has been recomended from friends of mine, i use viagra but with no effect on PE,
    Thanks again

    1. Ethan Green

      Hi Mody
      Thanks for the compliment – I’m glad you found the article useful. As far as I can see, there are no obvious warnings online from medical or drugs websites about mixing viagra and tramadol. If you choose to try this, I’d just take low doses to make sure you don’t react badly to them. Have you tried other techniques as well? Maybe using a delay spray with the viagra will help.

  14. I use Depaxotine and it is amazing. I last as much as I can now.
    Its side effects, are minimal.

    1. Ethan Green

      Hi Sam
      That’s good to hear! It’s always useful to hear from guys who had a positive experience with a treatment.

  15. hi…My Name is Mitkumar…i’m 25 years old….i have a very big problem is Early Dysfunction and its cause only that i have a very less fore skin on the tip of penis and my my penis is so sensitive so after the entering in vagina only 2 Minuit i had been discharged so my partner got very upset due this mine problems occurred every time….so please help me…and my penis foreskin is also less i don’t know why but will i grow foreskin again???? please help me cause now my married life would be the end of brake up….please help me……and suggest me some pill and how it will work for stop PE or ED……….

    1. Ethan Green

      Hi Mitkumar
      First of all, no you won’t grow new foreskin if you have a shorter one. Secondly, perhaps you might benefit from using a thicker condom than usual, or even a delay condom. This can help with the sensitivity. Either that or a spray. I can understand your desire for a pill, but unfortunately there really aren’t any which are amazing. You could try dapoxetine, but that’s unlikely to add more than 2-3 minutes. Alternatively, your doctor can prescribe you anti-depressants which do work for some guys. But they come with all kinds of risks. My advice would be to try a condom and/or spray first. If that doesn’t work, you could try dapoxetine or ask for your doctor’s help.

    2. Hi,I had same problem like you.. But I do sex 2 or 3 time a month. Ok how I recover from that problem just going to share with you. First after meeting with doctors I m started to take paroxetine which is antidepressants pills and with that on sex day I add Viagra.. So on first sex I do quickly pe but in second time sex I can perform well. But please remind that antidepressants pills has some side effects.. Good luck

  16. Just discovered this site today.. Great site indeed and great job you’re doing..Ethan. Really helping out. From comments and your diligent responses have already enlightened me on d drugs to try and those not to try.
    Thanks and keep it up.

    1. Ethan Green

      Hi Oscar
      Thanks for your comment and your kind words. I’m really glad you found the website helpful!

  17. Ethan, great site. Did you experience any side effects from Tramadol? Did you feel addicted to it? Did it make you less alert, groggy, etc and lessen libido? Did you try out any PDE5 (like Viagra)? If yes, how did it work for you? Thanks.

    1. Ethan Green

      Hi Robby
      Thanks for your comment and compliment about the site – much appreciated!
      Yes, I definitely felt less alert when I took tramadol, but I don’t recall a libido problem. I actually tried viagra recently, as I was visiting Brazil where you can buy it in any chemist, unbelievably. I’m planning on writing about it soon, but yes, it definitely helped me both keep an erection for longer (and was harder too) and last longer. Apart from some headaches it was pretty awesome really.

      1. Hi guys. Great site indeed. Also am suffering from PE. Now..Ethan…what worked great viagra or tramadol? I have read a lot of scientific research on PE and believe dapoxetin 60 mg 30-60 minutes before sex apparently double or triple the time to ejaculation. The superiority of Dapoxetin is however is in its on demand status and body metabolize it and out of your body quickly. All other drugs and antidepressants for PE remain in the body and you need to take them daily as if you are suffering from depression and has numerous side effects. Regret Dapoxetin still not approved by FDA but you can buy it in europe or Asia. Lots of so called on line drug stores sell dapixetin but who knows what tgey are selling. In USA you can ask your doctor for paroxtine 20 mg which has same formula as dapoxetin but is not on demand and you must take it daily. In one study paroxetin was far more superior than dapoxetin for PE. But again who wants to take it daily.

        1. Ethan Green

          Hi Sam
          Thanks for your comment, and I’m glad you liked the site – that’s always nice to hear. That’s actually a very good question, and not one I’d thought about until reading your comment. To be honest, it’s kind of impossible to answer unfortunately. I took the tramadol ages ago and the Viagra very recently. And I have much better control now than I did at the time I took the tramadol.

          If I think about it just in terms of the difference it made to me at the time, I’d say tramadol had a more powerful effect. But that’s because my lasting time wasn’t that great to start with, so for me it was kind of a miracle.

          With the Viagra, I’m more used to lasting longer naturally these days, so although I felt like I had great control, I do sometimes have that feeling anyway. But there’s no doubt it gave me a good boost.

          So in some ways, I’d say both had a very positive effect on my stamina. However, the Viagra also gave me serious erections, whereas the only other effects of the tramadol are negative.

          I also agree with what you say about not wanting to take pills on an on-going basis. The idea of taking anti-depressants for PE is terrible in my eyes. Dapoxetine is definitely better as you take it on demand.


  18. Hi. I am 32 years old, married and have a 17 months old boy. I have been married for three and half year now. Before marriage I never had a p.e problem I used to last for a a good 8 to 12 minutes after entering the Vigina. But now I sometimes last a 1 or sometimes I ejaculate a few seconds after I enter the Vigina. I am thinking the reason for this is past. I was an alcoholic for 10 years, drinking one or two bottles daily and used to smoke 15 to 30 cigarettes of Hashish ( Hash) daily. So I am thinking the reason I used to last long and now ejaculate tools soon is the same. Plus watching porn and ejaculating quickly to finish up did not help either.
    I have tired delay sprays, delay condoms, herbal medicine but nothing seems to working. I have tried the stop and start technique but the only thing I got out of it is that I can stop and restart my pee lol….
    So now I was told that a low dose of Tramoline and taking it along side cailis about 1 to 2 hours before sex can help you last longer. I wanted to know what are your thoughts about all this.

    1. Ethan Green

      Hi Abdullah
      Thanks for your comment. To be honest, it’s possible that if you had sex before when drinking or smoking, that may have been numbing your sensitivity, so perhaps the problem has always been there. If not, then maybe it’s because you don’t have sex so often nowadays, or you just haven’t been doing the right things to keep yourself on a good arousal level.
      I don’t know if those pills will help – they might or might not. You just don’t know until you try them.
      My advice would be to also look into trying natural techniques. It could be that all you need is some instruction and ideas for keeping yourself calm. The start stop technique usually helps though. How long have you practiced it for?

  19. Abdul Kharim Eugenio

    I want to buy premature ejaculation medicine but I don’t know How to order, I’m here now Jizan K.S.A.
    Abdul Kharim

    1. Ethan Green

      Hi Abdul
      i don’t have any ordering information for medication because I only do reviews, amd to be honest, I don’t really recommend many pills so I haven’t said where to get them from a lot of the time. So you would have to look on the internet for a company that ships to you.

  20. Which medical and where available Priligy pills ?
    How to find in India ?

    1. Ethan Green

      Hi Bhushan
      Thanks for your comment. I’m not sure where’s the best place to get it in India. You’d need to do some research to find a pharmacy you feel you can trust.

  21. Can paxil cure PE for good if taken on a daily basis for a period of 12 weeks for instance?

    1. Ethan Green

      Hi Josh
      No, it won’t cure it. Even if it helps you during the time you take it, once you stop taking it the problem will possibly return, unless the psychological boost from lasting longer has a more permanent effect. But I doubt it will cure it.

  22. You are a real genius & a complete professional, I might try tramadol, hope it help me solved this ‘acquired’ dreaded problem permanently, thanks so much.

    1. Ethan Green

      Thanks Lema!
      Good luck if you try it, and let us know if it helped or not.

  23. Hi
    I read it all , i’m using now anafranil and it is wonderful
    But it have 2 problem
    1- headaches
    2- when i eat this for example @ 8:00 pm It will start for safe 1:00 am & between this period i feel my thinking not clear
    3- the important thing is that i should eat with it something that make my … Have good stand up . Its happened with me one time when i eat it my … does not stand up

    pls i need some thing perfect for long time

    1. Ethan Green

      Hi Ayoub
      So basically the anafranil is giving you headaches and stopping you from getting an erection? My advice would be to speak to your doctor about this and see if they can offer an alternative which doesn’t have those side effects.

  24. Thanks for this helpful article. After reading it, I think I’m gonna try the natural ideas first instead of getting into pills or anything else. M

    1. Ethan Green

      Hi Michael,
      Glad you found it helpful, and I think that’s a very sensible choice. All the best with it!

  25. Thanks for your informative article. I’ve been wondering what I can use to improve my lasting time, and so naturally though there would be a pill for it. There is for most things these days! But after reading this, I will definitely think about my options.

    1. Ethan Green

      No problem Michael. I’m very happy you found it helpful.
      All the best and I hope you find something which works for you.

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