Tramadol For Premature Ejaculation: Effective But Risky

pile of yellow and green Tramadol capsulesThe search for the Holy Grail of a medical treatment for premature ejaculation sometimes leads to strange places.

So it’s no surprise that another drug, Tramadol, has been popping up in medical journals in recent years as a candidate.

A bit like Dapoxetine, Tramadol wasn’t designed for this purpose. It’s actually a synthetic opioid analgesic used for moderate to severe pain relief.

But individual guys and researchers have discovered that it can also help improve premature ejaculation. I’ll discuss and reference some of these research studies a bit later. But first I’ll talk about my experience of Tramadol, as I’ve seen first hand both the good and bad side of it.

The pain, the pleasure and the near dependency

A few years ago I had major surgery, and was given a healthy supply of Tramadol to take home from hospital to manage the pain. What they didn’t realise, and I’d forgotten, was that I’d also been given a large amount by my own doctor. I ended up with more than 200 x 50mg pills.

Around a month after the surgery I was able to have sex again. One day I felt some pain returning, so decided to take a 50mg tramadol pill (I’d been off them for about a week). I then discovered to my delight that I lasted roughly 3 or 4 times longer than I used to.

So I decided to test if it was the tramadol by using them once or twice more, and then also without. It turns out it was definitely the tramadol helping.

Sounds great so far doesn’t it?

The problem was though that I twice experienced an issue with dependency on the tramadol developing. Firstly, I was craving a top-up every 6 hours for pain relief when taking them after surgery. It took a conscious effort to cut down and stop.

Secondly, I was loving the fact that my sex life was much better with my accidental discovery later on. I remember thinking to myself that this was great, and I should get some more so I could take them every time I had sex.

Not so great after all then!

Luckily for me I was strong-minded enough to cut down after the surgery. And I also knew that taking them long-term for sex wasn’t yet proved to be safe. I was also getting some side-effects like dizziness and just feeling weird (for want of a better description) when taking them.

My experience was obviously just one person’s, and very subjective. Nonetheless it does seem to highlight three key points that researchers make:

  • That Tramadol can help with premature ejaculation.
  • That it can cause side effects.
  • That it can lead to problems with dependency.

What researchers have found

In 2012 British researchers published a review of 5 studies into using tramadol to treat premature ejaculation. Interestingly, they also attempted to explain how it actually works.

They say that although it’s still not totally clear, there are two possible actions that occur. They explain that it works as a weak μ-opioid receptor agonist. But then go on to say that the more likely explanation is that it inhibits neuronal re-uptake of serotonin and norepinephrine.

Effects of tramadol on lasting time

In their review of the 5 studies published between 2006 and 2012, this is a brief summary of what they found:

Study 1

After 8 weeks of 50mg tramadol, the average lasting time of guys went from just 19 seconds to 243. That’s 13 times longer.

Study 2

After 8 weeks on 25mg tramadol, the average time increased from 70.2 to 442.2 seconds. So this was 6.3 times longer.

Study 3

This study actually compared tramadol with paroxetine. They found that the paroxetine group were lasting longer, and that the tramadol group had less rigid erections.

Study 4

They tested out both a dose of 62mg and 89mg, finding a respective increase of 2.4 and 2.5 times.

Study 5

They found that with a dose of 25mg, there was an increase in lasting time from 38.83 to 154.67 – 4 times longer.

The other findings of note are that in all the studies guys reported a significant increase in their sexual satisfaction. And also their partners said they were more satisfied. You would imagine as such, but that does show that guys were happy with that kind of increase in time.

Side effects

Across those 5 studies they say that the tramadol was well tolerated, and that the side effects experienced were only mild. Although in my view when one study says that 28.1% reported nausea, I wonder what the meaning of ‘well tolerated’ actually is!

These are the main side effects that guys reported:

  • nausea
  • somnolence
  • erectile dysfunction
  • vertigo
  • dyspepsia
  • headache
  • vomiting
  • dizziness

Potential problems with using tramadol

It’s a standard thing in research journals to find at the end a kind of disclaimer where they have to talk about all the things that were potentially wrong with their own study. And things that still need to be done in the future. And of course potential problems with the subject of the study.

So even though they conclude that tramadol appears to be an effective treatment, they also describe these potential problems:

  • They only know how well it works, and how safe it is, up to 18 weeks. So the long-term effectiveness and safety of using tramadol is still not known.
  • They don’t really know how well it compares to other drugs, like SSRI anti-depressants. Except the paroxetine study which suggests paroxetine did better.
  • That there are serious concerns about the potential for tramadol abuse and dependence.

Tramadol dependency

So now we know that tramadol can help many guys with premature ejaculation. The major concern though doesn’t seem to be side effects, but becoming dependent. This study isn’t the only one to mention it – this article for example also suggests that it’s a concern.

So just how bad is the risk of guys abusing or becoming addicted to tramadol? Well, it’s not as bad as you might think, according to a 2012 research study in Egypt.

They quote another piece of research from 1999 as saying that in the United States the rate of addiction is 1 in 100,000. Something the review article also mentions, though they also say that’s a significant number.

It appears from looking at other sources also, the risk is mainly with people who have a history of drug abuse. Maybe that explains why although I personally found a craving for the tramadol developing, I was able to stop taking it without too much trouble once I decided to.


It appears then that tramadol could be an efficient way of helping guys deal with premature ejaculation. But as with all other medical treatments, it’s only a temporary solution and can cause other problems.

You do run the risk of having side effects – it’s an opioid after all, and so a strong drug. And there’s still much research needed into the long-term effectiveness and whether it’s better than other treatments.

There’s also the risk of addiction, dependency, abuse or whatever you want to call it. And although researchers say the risk is minimal, it could still happen to you. And if you have a history of drug use or addiction – I would try something else instead.


You might also like to read about other options for dealing with premature ejaculation. An easy way to deal with physical sensitivity is to use one of my recommended desensitizing sprays.

And if you’re interested in dealing with the problem naturally and permanently, I highly recommend checking out these premature ejaculation ebooks.



266 CommentsLeave a comment

  • hi. how many hours before sex should I take tramadol , lets say 100 mg?Also when should be the next dosage be taken after the first one? thanks a lot .

    • Hi RK
      The time it takes depends on the person, dosage and type. It could be 20 minutes or even up to longer than an hour. The time between doses will also depend on the person and the type. The pack should tell you, but it’s also good to check with a doctor.

  • Hi ethan..i jave read about the use of tram..i have a plan to use a 100mg..but i wanna know..does it start working immediately you use it..or am i suppose to like chilll for 30mits or 1hr…or let me put it this way..can i use it immediately i wanna have sex or should i use it just the day i want to have sex & and it will take effect just any time i want to enhage in it..your reply is highly needed to this.thanks

    • Hi Nathan
      I don’t know of any specific bad interactions between the two, but it’s always good to check with a doctor first before taking strong drugs like these.

    • Hi Sudhir
      I don’t think your age automatically stops you, but it’s always good to check with a doctor before taking a strong drug like this.

  • I do take 1000 mg I always feel week if I don’t take it right now I’m so tired And I think I need to take at least 500mg to be ok without it I don’t feel good or in mood to play I just get tired more but once I’m on it I feel comfortable and ok with it

    • Hi Yinkee
      Do you take it every day? If so, it’s not a good idea unless you have a medical need for pain relief, which is why you feel strange.

  • Am James, Am 21 Yr Old I Dnt Knw If I Have PME, But I Mustabate And Wash Porn Regularly For Long Nw And I Have Not Had Sex Be4 Bt I Want To Have Just Once With My Girl Just Ones Before Mariage Pls Sir Hw Many Dosage Of Tramadole Can I Use To Have Sex Incase It May Hapen I Have Premature Ejaculation To Avold Unsatisfaction And Embarasment N Breakup And Also If I Used Tramadole Once To Have Sex, Wil Dey Be Any Side Effect?

    • Hi James
      If you’ve never had sex, and don’t know if you have a problem or not, I would think positively and assume you will be fine! Taking a strong drug like tramadol before you have sex the first time just isn’t a good idea, in my opinion. It’s better to be yourself, relax and enjoy the moment! There’s no point taking medication for something just because it could happen!

    • Hi Frank
      I’m not really qualified to recommend a diagnosis in specific cases. My standard advice is to start with the lowest possible dose. And of course, check that it’s ok considering your current health and other medication you take. The ideal would be to talk to your doctor about it, just to be sure it’s ok for you to take.

    • hi there
      Technically, it’s best to ask a doctor for their advice based on your own medical history. My opinion is that it’s best to start with the lowest possible dose, like 25mg and see if that helps, before considering taking more.

  • I’m a starter, if i take 25mg how long will i last. and should i take the green or yello. and how many capsule should i take before start?

    • Hi Chiboy
      It’s impossible to say how long you’ll last. It depends on different factor. I can’t advise you on which ones to take because there are many different types, and I’m not a doctor or pharmacist. Sorry!

  • hi Ethan, I started with 200mg some years back, it was perfect cos i lasted up to an hour. wat i realized was as time goes on my dosage increased up to 600mg before lastin to an hour on bed. though it was cool but need your advice on how to control my dosage.
    from nigeria

    • Hi Robo
      That’s a large dose of tramadol to be taking. I’ve seen some websites recommend a maximum of 400mg in a day. If you feel you have a problem with addiction, then it might be good to speak to your doctor about it. Otherwise, you might need to cut down yourself because that’s a dose which could have dangerous effects long-term.

  • Hi, I am glad I found this interactive session down here.
    Now, for over a year I’m in a relationship that we have to see once in 2 or 3 months. Before then, I cum in less than a minute. But she’s way more experienced but I don’t want to let it come in between us. Knowing fully well my problem, I got an advice on Tramadol. So I took 100mg on the first night together. I had a night of no PE. I was excited within me. I tried it again and the same thing. I didn’t cum for over 7hrs(had sex again in the morning)
    The next time we had sex, I couldn’t lay my hands on tramadol so I went on…but had sex more than the usual NO-TRAMADOL me. Lasted for about 6 to 7mins. Then again, I tried another round but I came quick. In less than 2minutes.
    I tried to reduce my dosage to 50mg the next day and I still came quick. I’d really appreciate your advice on this.

    • Hi Jonze
      So it all makes sense – the tramadol helped you last longer. When you didn’t take it, you came quickly. Then you tried a lower dose and it didn’t help. Either your body was processing the tramadol differently, or the dose just wasn’t right. Did you try 100mg again at some point?

  • Do I understand it correctly that in USA (I suppose you’re from there) is Tramadol freely available medication without prescription? Or all of you have it from black market or from your doctor?

    • Hi Peter
      No, it’s not easily available without a prescription in the US. I think most people either buy it online – which is risky of course – or more often than not, have it prescribed for pain and then either accidentally discover it helps sexual stamina, or they knew about it somehow already.

  • wen I take it b4 having it normally work well for me but going for second rounds bcum a problem. my dick will not stand & even if it stand it will not b strong to have another sex, so what should I do to b able to b going for second and 3rd times ?

    • Hi prince
      I think perhaps either take less tramadol, or you might have to accept that it’s having a bad effect on you, despite working the first time around. It could also be that because you’re lasting longer, and presumably having more intense sex, it could be that you just need to wait longer before having sex again.

  • I’m 30. I recently began taking tramadol following a surgery. I have struggled with PE for some time. With my ex, After just a minute or 2, sometimes even briefer, I would first get the sensation that i was on the edge of ejaculation. My tramadol regiment was very minimal, when I woke up I took 1.5 pills (75mg) and it served as a mood-elevator helping me to start my day. On nights when I would end up having sex, I would sometimes pop a half-pill (25mg) during the pre-coitus interaction. This would often allow me to have care-free, stress-free, anxiety-free, sex without only thinking about busting fast. I would typically last 30min, an hour. I would also sometimes take 75mg of tramadol and a $10 gas station boner pill, and would have several 30-40 minute sessions back to back. It’s great for a one-time encounter but so easy to get hooked on the success of good sex. Its super addicting. I have yet to find a better alternative :/

    • Hi Hal
      Thanks for your comment. You describe pretty much the exact situation that many men will find and have to deal with. Tramadol can be very effective, and the great feeling that it gives you when you have sex for so much longer than normal can be hard to resists. So not only is the tramadol chemically addictive, the results it gives you are also addictive. It’s a trick line to walk…

  • Hi, I’m kay.. I’m do ejaculate quickly like within 30 secs.. so i heard of tramadol but have not started taking it..
    My question is how many grams and dosage should i take so as last up to 30mins-1hour?

    • Hi Kay
      I don’t think it’s a case that a certain dose gives a certain time you’ll last for. It just can’t be calculated like that as there are two many factors at play. My advice is to start with the smallest possible dose, like 25mg, and see if that helps you.

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