Tramadol For Premature Ejaculation: Effective But Risky

pile of yellow and green Tramadol capsulesThe search for the Holy Grail of a medical treatment for premature ejaculation sometimes leads to unexpected places.

So it’s no surprise that another drug, Tramadol, has been popping up in medical journals in recent years as a potential solution.

A bit like Dapoxetine, Tramadol wasn’t designed for this purpose though; it’s actually a synthetic opioid analgesic used for moderate to severe pain relief.

But individual guys and researchers have discovered that it can also help improve premature ejaculation. I’ll discuss and reference some of these research studies a bit later.

But first I’ll talk about my experience of Tramadol, as I’ve seen first hand both the good and bad side of it.

The pain, the pleasure and the near dependency

A few years ago I had major surgery, and was given a large supply of Tramadol to take home from hospital to manage the pain. What they didn’t realize, and I’d forgotten, was that I’d also been given a large amount by my own doctor. I ended up with more than 200 x 50 mg pills.

Around a month after the surgery I was able to have sex again. One day I felt some pain returning, so decided to take a 50 mg Tramadol pill (I’d been off them for about a week). I then discovered to my delight that I lasted roughly 3 or 4 times longer than I used to.

So I decided to test if it was the Tramadol by using them once or twice more, and then also without. It turns out it was definitely the Tramadol helping.

Sounds great so far, right?

The problem was though that I twice experienced an issue with dependency on the Tramadol developing. First, I was craving a top up every 6 hours for pain relief when taking them after surgery. It took a conscious effort to cut down and stop.

Second, I was loving the fact that my sex life was much better with my accidental discovery later on. I remember thinking to myself that this was great, and I should get some more so I could take them every time I had sex.

Not so great after all then!

Luckily for me I was strong-minded enough to cut down after the surgery. And I also knew that taking them long-term for sex wasn’t yet proved to be safe. I was also getting some side effects like dizziness and just feeling weird (for want of a better description) when taking them.

Of course, this was just my experience Nonetheless it does seem to highlight three key points that researchers make:

  • That Tramadol can help with premature ejaculation.
  • That it can cause side effects.
  • That it can lead to problems with dependency.

What researchers have found

In 2012, British researchers published a review of 5 studies that had looked at Tramadol to treat premature ejaculation. Interestingly, they also attempted to explain how it actually works.

They say that although it’s still not totally clear, there are two possible actions that occur. They explain that it works as a weak μ-opioid receptor agonist. But then go on to say that the more likely explanation is that it inhibits neuronal re-uptake of serotonin and norepinephrine.

Effects of Tramadol on lasting time

In their review of the 5 studies published between 2006 and 2012, this is a brief summary of what they found:

Study 1

After 8 weeks of 50 mg Tramadol, the average lasting time of guys went from just 19 seconds to 243. That’s 13 times longer.

Study 2

After 8 weeks on 25 mg Tramadol, the average time increased from 70.2 to 442.2 seconds. So this was 6.3 times longer.

Study 3

This study actually compared Tramadol with paroxetine. They found that the paroxetine group were lasting longer, and that the Tramadol group had less rigid erections.

Study 4

They tested out both a dose of 62 mg and 89 mg, finding a respective increase of 2.4 and 2.5 times.

Study 5

They found that with a dose of 25 mg, there was an increase in lasting time from 38.83 to 154.67 – 4 times longer.

The other findings of note are that in all the studies guys reported a significant increase in their sexual satisfaction. And also their partners said they were more satisfied. You would imagine as such, but that does show that guys were happy with that kind of increase in time.

Side effects

Across those 5 studies they say that the Tramadol was well tolerated, and that the side effects experienced were only mild. Although in my view when one study says that 28.1% reported nausea, I wonder what the meaning of ‘well tolerated’ actually is!

These are the main side effects that guys reported:

  • nausea
  • somnolence
  • erectile dysfunction
  • vertigo
  • dyspepsia
  • headache
  • vomiting
  • dizziness

Potential problems with using Tramadol

It’s a standard thing in research journals to find at the end a kind of disclaimer where they have to talk about all the things that were potentially wrong with their own study.

So even though they conclude that Tramadol appears to be an effective treatment, they also describe these potential problems:

  • They only know how well it works, and how safe it is, up to 18 weeks. So the long-term effectiveness and safety of using Tramadol is still not known.
  • They don’t really know how well it compares to other drugs, like SSRI anti-depressants. Except the paroxetine study which suggests paroxetine did better.
  • That there are serious concerns about the potential for Tramadol abuse and dependence.

Tramadol dependency

So now we know that Tramadol can help many guys with premature ejaculation. The major concern though doesn’t seem to be side effects, but becoming dependent. This study isn’t the only one to mention it – this article for example also suggests that it’s a concern.

So just how bad is the risk of guys abusing or becoming addicted to Tramadol? Well, it’s not as bad as you might think, according to a 2012 research study in Egypt.

They quote another piece of research from 1999 as saying that in the United States the rate of addiction is 1 in 100,000. Something the review article also mentions, though they also say that’s a significant number.

It appears from looking at other sources also, the risk is mainly with people who have a history of drug abuse. Maybe that explains why although I personally found a craving for the Tramadol developing, I was able to stop taking it without too much trouble once I decided to.


It appears then that Tramadol could be an efficient way of helping guys deal with premature ejaculation. But as with all other medical treatments, it’s only a temporary solution and can cause other problems.

You do run the risk of having side effects – it’s an opioid after all, and so a strong drug. And there’s still much research needed into the long-term effectiveness and whether it’s better than other treatments.

There’s also the risk of addiction, dependency, abuse or whatever you want to call it. And although researchers say the risk is minimal, it could still happen to you. And if you have a history of drug use or addiction – I would try something else instead.

Your views

Have you tried Tramadol to help you last longer? Did it work, and did you have any side effects? Let me know in the comments below.


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  • Yes I did but I never suspected that until the last time I had seen with my wife, I noticed that I lasted longer than my usual 10secs. I thought maybe it was because of the condom that I used. The reason for my doubts was that I took it (200ml) just a dose before I went to sleep majorly because of my sleeplessness but the next morning when I had set with my wife, I look great but I still feel dizzy and partial headache….. Thanks for this info

  • Hi

    At 49 I’m in a relationship with a lady half my age.. The sex is amazing, but off late I find it difficult to last longer than 2-4 minutes.

    This has been happening for the past 6 months and while I manage to ensure my lady is left satisfied, I feel miserable not being able to last longer.

    I have managed to procure Tamadis 50mg pills but I’m worried about using them, reading several comments here My, biggest worry is not having a strong erection. I have no issues rising to the situation, watching porn and masturbating I can last above 7 or 8 minutes, It’s just that once I penetrate I don’t seem to be able to last longer than 3 or 4 minutes sometimes even less.

    I would like to try this medicine out tonight, but by breaking the tab into 2 I’m hoping to halve the dose and see what happens. Wondering how it would react to the 1 ltr of beer I have consumed and the 2 tokes of weed? going to wait 2 hours after consuming these to take the hopefully 25mg pill and an hour later try making love to my lady.

    Will let you know how it all pans out..

    • Hi Horatio
      I can understand your concern, and you’re right to be cautious when using it. Having said that, taking it with alcohol and weed isn’t exactly being cautious! I’d be interested to know how it went for you, and also if you noticed a difference in taking it with alcohol and marijuana, and just on its own if you try that too (which in my opinion is a better option!). If you’re worried about erection problems too, I’d definitely stay away from the booze and weed.

    • Hi
      My advice is always to first check with your doctor, and to take the smallest dose possible as it’s a strong drug.

  • I was told about it by a friend, then I tried it the first time with 150mg, I ended up lasting for a whole day without coming, yes with more strength to do more. Note, after or this lasting period, for two to three days later, i keep falling asleep both in the afternoon and in the night. any little chance I have or idle, I fall asleep even intended to go and see a doctor. then I deride first to make research to see if its the one causing my sleeping all the time. Well, I do like to know what are the required dosage and how long do one have to take it and stop. I am 30 of age.

    • Hi Benedict
      I’m not surprised you felt sleepy taking 150mg – it’s quite a high dose. As per the article, you can take much less to get the desired effect.

    • Hi
      It depends on various factors, but probably not a day, no. Tramadol usually wears off in a few hours.

    • Hi
      Once you wait for it to work – like 30-60 minutes – then yes, it can help you last longer the first day you take it.

  • 100% helped me, I had an issue and thought I would try this out and I must say it worked a treat, I went from under 2 mins to over 20 only down side was it took longer to get it up than normal. I took 100mg slow release about an hour ish before, I have used it 2 times for this purpose and it is priceless…

    • Hi
      Thanks for sharing your experience. Yes, it does work well, but like you say, can also cause some other problems. Have you tried taking a smaller dose to see what happens?

  • Pls, can tramadol make someone who barely last for 2mins get up to 14mins, and what’s the best milligram to take before having sex

    • Hi
      It’s impossible for me to say for sure in your case, but I think it could have a big effect for some men. You just won’t know until you try it. I would start with the smallest possible dose, but also ask your doctor first to check it’s safe for you to take.

    • Hi Moses
      I recommend starting with the lowest possible dose, and getting your doctor’s advice first. No, it doesn’t give any strength to your penis – just helps you last longer.

  • Hi Ethan
    I have lifelong PE problem. Nothing seems to work with me.If I start using Tramadol for it, what starting dose you suggest. Secondly is it to be taken regularly for effectiveness or just before the actual sexual activity. For instance I have sex twice a week so if I take twice 50mg, 2 hours before the activity will it work wonders? I hope it wont give side effects with this frequency

    • Hi Sohail
      If you’re going to use it, start with the lowest possible dose is my advice. But even better is to talk to your doctor about it to make sure it’s safe for you considering your medical history.
      In terms of taking it, you only need to take it each time you have sex.

  • I haven’t found any side effects after taking this tramadol for my premature ejaculation. hmmm I should be checking it for now after reading

    • Hi Dominic
      Not everyone will have noticeable side effects. But yes, I’d still be careful using it in the long term.

  • Hello Ethan,

    What about those that have injuries and the doctors gave tramadol that will last for 3-6 months, along the line, if the patient take it to reduce pain and still make love the same, will there be any side effect?

    • Hi Mr Tilo
      I see your point, but unfortunately the side effects are still a risk even if you’re officially taking the tramadol for the ‘normal’ reason of pain relief.